MiR-449 improves cardiac function by regulating HDAC1 and cTnI.

CONCLUSIONS: MiR-449 can regulate the acetylation of the histones H3K4 and H3K9 of the GATA element in the cTnI promoter region, thereby recruiting the transcription factor GATA4 to the cTnI promoter region, upregulating the cTnI gene expression, and improving cardiac function in elderly mice with low expression of cTnI. PMID: 33378032 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research