Inhaled corticosteroids and angiotensin-converting enzyme-2 in COPD
Finney et al1 elegantly showed in mice that inhaled corticosteroid (ICS) down-regulated the severe acute respiratory syndrome coronavirus-2 entry receptor angiotensin-converting enzyme 2 (ACE2) via suppression of type 1 interferon. It was also found that in 36 patients with chronic obstructive pulmonary dis ease (COPD), the use of ICS was associated with reduced expression of ACE2 compared with non-ICS users, whereas ACE2 expression is increased in cultured bronchial epithelial cells from patients with COPD and in turn suppressed by fluticasone propionate.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Brian Lipworth, Rory Chan, Chris Kuo Tags: Correspondence Source Type: research
More News: Allergy | Allergy & Immunology | Chronic Obstructive Pulmonary | Coronavirus | Corticosteroid Therapy | COVID-19 | Flonase | Flovent | Respiratory Medicine | SARS