Diverse consequences of hexosamine biosynthesis in cardiovascular disease

In the stressed heart, metabolic remodeling precedes most, if not all, other pathophysiological changes [1]. When the heart is not stressed, it relies on fat for energy provision, with glucose being an additional energy source, while lactate, ketone bodies, and amino acids contribute as well, but do so only to a small extent. As a metabolic omnivore, the heart switches its nutrient preference towards more glucose under stress. After uptake, glucose is converted to pyruvate in the glycolytic pathway (Fig.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Tags: Letter to the editor Source Type: research