The PGE2 receptor EP3 plays a positive role in the activation of hypothalamic-pituitary-adrenal axis and neuronal activity in the hypothalamus in rats under immobilization stress.

CONCLUSIONS: These results suggest that immobilization stress may result in increased activation of the HPA axis and neuronal activity through regulating the function of the EP3 receptor. PMID: 33370588 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33370588?dopt=Abstract

Source: Brain Research Bulletin - December 25, 2020 Category: Neurology Authors: Lv L, Bai D, Ma Y, Liu K, Ma Y Tags: Brain Res Bull Source Type: research