Naringenin improves depressive- and anxiety-like behaviors in mice exposed to repeated hypoxic stress through inhibition of oxido-inflammatory mediators and NF-kB/BDNF expressions.
Naringenin improves depressive- and anxiety-like behaviors in mice exposed to repeated hypoxic stress through inhibition of oxido-inflammatory mediators and NF-kB/BDNF expressions.
Brain Res Bull. 2020 Dec 25;:
Authors: Olugbemide AS, Ben-Azu B, Bakre AG, Ajayi AM, Femi-Akinlosotu O, Umukoro S
Abstract
Oxidative and inflammatory signaling pathways have been identified as important targets for mitigating hypoxic stress-induced neurological complications. Thus, the effects of naringenin, a potent antioxidant, anti-inflammatory and neuroprotective bioflavonoid on hypoxic stress-induced depressive-like and anxiety-related behaviors in mice, and the underlying molecular mechanisms were evaluated in this study. Forty-two male Swiss mice were distributed into 5 groups (n = 7). Mice in group I (non-stress control) and group 2 (stress-control) both had vehicle (5% DMSO), while groups 3-5 received naringenin (10, 25 and 50 mg/kg), intraperitonally. Thirty minutes later, mice in groups 2-5 were subjected to 15 min hypoxic stress, daily for 14 days. Locomotor activity, anxiety and depression were evaluated on day 15. The mice brains were processed for malondialdehyde, glutathione, superoxide-dismutase, catalase, tumor necrosis factor-alpha (TNF-α) and interleukin-1β assays. The serum corticosterone concentration and expressions of the brain immunopositive cells of iNOS, NF-kB and BDNF as well as histomorphological changes of the amygda...
Source: Brain Research Bulletin - Category: Neurology Authors: Olugbemide AS, Ben-Azu B, Bakre AG, Ajayi AM, Femi-Akinlosotu O, Umukoro S Tags: Brain Res Bull Source Type: research
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