CaMKII γ regulates the viability and self-renewal of acute myeloid leukaemia stem-like cells by the Alox5/NF-κB pathway.

In conclusion, our study describes a new role for CaMKIIγ as a stem-like cell marker that is highly regulated by the Alox5/NF-κB pathway in AML stem-like cells. CaMKIIγ can participate in the viability and self-renewal of AML stem-like cells by regulating the Alox5/NF-κB pathway. PMID: 33369192 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33369192?dopt=Abstract

Source: International Journal of Laboratory Hematology - December 25, 2020 Category: Hematology Authors: Cheng JH, Zhang WJ, Zhu JF, Cui D, Song KD, Qiang P, Mei CZ, Nie ZC, Ding BS, Han Z, Ding ZE, Zheng WW Tags: Int J Lab Hematol Source Type: research