Loss of fibroblast growth factor receptor 2 (FGFR2) leads to defective bladder urothelial regeneration after Cyclophosphamide injury

Cyclophosphamide may cause hemorrhagic cystitis and eventually bladder urothelial cancer. Genetic determinants for poor outcomes are unknown. We assessed actions of fibroblast growth factor receptor 2 (FGFR2) in urothelium after Cyclophosphamide. Conditional urothelial deletion of Fgfr2 (Fgfr2KO) did not affect injury severity or proliferation of Keratin 14+ (KRT14+) Basal progenitors or other urothelial cells one day after Cyclophosphamide. Three days after Cyclophosphamide, Fgfr2KO urothelium had defective regeneration, fewer cells, larger Basal cell bodies and nuclei, paradoxical increases in proliferation markers and excessive replication stress versus controls.

Source: American Journal of Pathology - December 29, 2020 Category: Pathology Authors: Sridhar Tatarao Narla, Daniel Scott Bushnell, Caitlin Marie Schaefer, Mehdi Nouraie, Justin T. Tometich, Timothy W. Hand, Carlton Matthew Bates Tags: Regular Article Source Type: research