A review of accelerator-produced Ga-68 with solid targets.

A review of accelerator-produced Ga-68 with solid targets.
Curr Radiopharm. 2020 Dec 23;:
Authors: Becker KV, Chernysheva M, Barnhart TE, Gagnon K, Engle JW
Abstract
Ga-68 is a positron-emitting nuclide that has recently achieved clinical acceptance as the diagnostic radionuclide in PET tracers used for theranostic studies of Lu-177 labeled therapeutic drugs due to the ease of access provided by Ge-68/Ga-68 generators. An alternative method of production currently being explored uses accelerators to form Ga-68 directly. This review of Ga-68 production strategies discusses available accelerator targetry at a range of beam energies and intensities, the many radiochemical separation techniques available to isolate Ga-68 from irradiated targets, isotopically enriched target material recovery, and the implications of these techniques for downstream radiolabeling applications.
PMID: 33357189 [PubMed - as supplied by publisher]

Source: Current Radiopharmaceuticals - December 29, 2020 Category: Radiology Tags: Curr Radiopharm Source Type: research