CYP1A1 enzymatic activity influences skin inflammation via regulation of the AHR pathway

The Aryl hydrocarbon Receptor (AHR) is an environmental sensor and transcription factor activated by a variety of man-made and natural ligands, which has recently emerged as critical regulator of homeostasis at barrier organs such as the skin. Activation of the AHR pathway down-modulates skin inflammatory responses in animal models and psoriasis clinical samples. Here, we identify CYP1A1 enzymatic activity as a critical regulator of beneficial AHR signalling in the context of skin inflammation. Mice constitutively expressing Cyp1a1 displayed increased CYP1A1 enzymatic activity in the skin, which resulted in exacerbated immune cell activation and skin pathology, mirroring that observed in Ahr deficient animals.

Source: Journal of Investigative Dermatology - December 29, 2020 Category: Dermatology Authors: Mariela Kyoreva, Ying Li, Mariyah Hoosenally, Jonathan Hardman-Smart, Kirsten Morrison, Isabella Tosi, Mauro Tolaini, Guillermo Barinaga, Brigitta Stockinger, Ulrich Mrowietz, Frank O. Nestle, Catherine Smith, Jonathan N. Barker, Paola Di Meglio Tags: Original Article Source Type: research