Epidermal class A scavenger receptor complexes are lipid raft-based and promote nucleic acid nanoparticle uptake
Scavenger receptors clear pathogens, transport lipid, and mediate polyanionic ligand uptake in macrophages, but their expression and role in skin is poorly understood. Although the epidermal barrier typically excludes nucleic acid entry, topically applied, spherically-arranged oligonucleotide nanoconjugates (spherical nucleic acids or SNAs) penetrate mouse skin, 3D skin equivalents, and human skin. We explored the mechanism of SNA uptake in normal human epidermal keratinocytes (NHEKs) and 3D skin equivalents.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Qian Song, Xiao-Qi Wang, Thomas R. Holmes, Michael Bonkowski, Eric W. Roth, Adam Ponedal, Chad Mirkin, Amy S. Paller Tags: Original Article Source Type: research