Optimization of fluconazole dosing for the prevention and treatment of invasive candidiasis based on the pharmacokinetics of fluconazole in critically-ill patients.

Conclusion: Substantial variability in fluconazole plasma concentrations in critically-ill adults was observed, where the majority of patients were underexposed. Fluconazole Cmin TDM guided dosing can be used to optimize therapy in critically ill patients. PMID: 33361296 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33361296?dopt=Abstract

Source: Antimicrobial Agents and Chemotherapy - December 23, 2020 Category: Microbiology Authors: Boonstra JM, Märtson AG, Sandaradura I, Kosterink JG, van der Werf TS, Marriott DJE, Zijlstra JG, Touw DJ, Alffenaar JWC Tags: Antimicrob Agents Chemother Source Type: research