Redox protein OsaR (PA0056) regulates dsbM and the oxidative stress response in Pseudomonas aeruginosa.

In this study, it was found that OsaR can indirectly inhibit transcription of oxyR In addition the gene cluster composed of PA0055, osaR, PA0057 and dsbM was identified, and the associated regulatory mechanisms and functions were elucidated. Our work not only provides a mechanistic understanding of antibiotic tolerance regulation in P. aeruginosa, but also has significant implications for redox regulation in human pathogens in general.
PMID: 33361299 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - December 23, 2020 Category: Microbiology Authors: Liu Y, Ma Y, Ma Z, Han X, Qi H, Andersen JB, Xu H, Tolker-Nielsen T, Qiao M Tags: Antimicrob Agents Chemother Source Type: research