Mutation in kars: a novel mechanism for severe anaphylaxis

Capsule summary: Mutation in KARS leads to an increase in MITF activity and mast cell release of proinflammatory mediators. Dysregulation of the KARS-MITF pathway can be an underlying mechanism resulting in anaphylaxis.

Source: Journal of Allergy and Clinical Immunology - December 29, 2020 Category: Allergy & Immunology Authors: Pau Rib ó, Yanru Guo, Juan Aranda, Erola Ainsua-Enrich, Arnau Navinés-Ferrer, Mario Guerrero, Mariona Pascal, Cinthia de la Cruz, Modesto Orozco, Rosa Muñoz-Cano, Margarita Martin Source Type: research