Lyme Disease Pathogenesis.

Lyme Disease Pathogenesis. Curr Issues Mol Biol. 2020 Dec 23;42:473-518 Authors: Coburn J, Garcia B, Hu LT, Jewett MW, Kraiczy P, Norris SJ, Skare J Abstract Lyme disease Borrelia are obligately parasitic, tick- transmitted, invasive, persistent bacterial pathogens that cause disease in humans and non-reservoir vertebrates primarily through the induction of inflammation. During transmission from the infected tick, the bacteria undergo significant changes in gene expression, resulting in adaptation to the mammalian environment. The organisms multiply and spread locally and induce inflammatory responses that, in humans, result in clinical signs and symptoms. Borrelia virulence involves a multiplicity of mechanisms for dissemination and colonization of multiple tissues and evasion of host immune responses. Most of the tissue damage, which is seen in non-reservoir hosts, appears to result from host inflammatory reactions, despite the low numbers of bacteria in affected sites. This host response to the Lyme disease Borrelia can cause neurologic, cardiovascular, arthritic, and dermatologic manifestations during the disseminated and persistent stages of infection. The mechanisms by which a paucity of organisms (in comparison to many other infectious diseases) can cause varied and in some cases profound inflammation and symptoms remains mysterious but are the subjects of diverse ongoing investigations. In this review, we provide an overview of virulence mechanis...
Source: Current Issues in Molecular Biology - Category: Molecular Biology Authors: Tags: Curr Issues Mol Biol Source Type: research

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Conditions like arthritis and gout that cause stiff and painful joints affect almost 1 in 4 adults in the United States, a new federal report says, and the numbers are growing as the population gets older.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Funding Opportunity RFA-AI-21-075 from the NIH Guide for Grants and Contracts. To expand our understanding of protozoan parasite persistence mechanisms and provide research tools and strategies to enable identification and credentialing of novel treatments for persistent protozoan pathogens.
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
Ivermectin is an over 30-year-old wonder drug that treats life- and sight-threatening parasitic infections. Its lasting influence on global health has been so profound that two of the key researchers in its discovery and development won the Nobel Prize in 2015. I ’ve been an infectious disease pharmacist for over 25 years. I’ve also managed patientsRead more …Ivermectin is a Nobel Prize-winning wonder drug originally appeared inKevinMD.com.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Meds Infectious Disease Source Type: blogs
The latest survey data indicate that more Americans have arthritis than ever before, possibly because of an aging population, worsening individual health, and economic factors.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Rheumatology News Source Type: news
Parasitol Res. 2021 Oct 18. doi: 10.1007/s00436-021-07341-2. Online ahead of print.ABSTRACTBiomphalaria spp. snails are intermediary hosts of Schistosoma mansoni, etiologic agent of intestinal schistosomiasis, one of the most important neglected tropical diseases. Biomphalaria straminea is an important intermediary host that possess a different phenotype to parasite infection but shows a large geographic distribution and high capacity of new ecologic niche invasion. Our purpose was to characterize for the first time the differentially expressed proteome in B. straminea during two times intervals after primary and secondary...
Source: Cell Research - Category: Cytology Authors: Source Type: research
CONCLUSIONS: M. pneumoniae infection should be actively sought in children developing immune-mediated diseases, including patients affected with JIA and, especially, in oligopolyarticular forms. There is some evidence that total serum IgE levels may tend to be increased in patients with oligopolyarticular JIA subtype and especially in those resulting as M. pneumoniae seropositive. However, further and focused research is needed to confirm these preliminary results and to clarify the relation between M. pneumoniae infection, atopic status, and immune-mediated arthritis.PMID:34660816 | PMC:PMC8514930 | DOI:10.1155/2021/6596596
Source: Journal of Immunology Research - Category: Allergy & Immunology Authors: Source Type: research
J Trop Med. 2021 Oct 6;2021:7239291. doi: 10.1155/2021/7239291. eCollection 2021.ABSTRACTBACKGROUND: The leaves of Leea rubra contain an abundance of phenolic constituents and have medicinal uses as antipyretic and diaphoretic agents and are also used in the treatment of stomach ache, rheumatism, arthritis etc. In spite of the traditional uses, data on the scientific evaluation of the plant are not sufficient. So, the present study was designed to evaluate the protective role of the extract against oxidative damage to DNA and human erythrocytes as well as antitumor and antibacterial activities against some resistant bacter...
Source: Journal of Tropical Medicine - Category: Tropical Medicine Authors: Source Type: research
Ticks and the diseases they carry have long been recognized as health concerns, especially in the warmer months when ticks (and humans) are more active. Ticks wait on grass tips or shrubs to latch onto new hosts when they brush by. Most of the hosts are animals, but a few tick species do bite and feed on humans. While doing so, they can transmit bacteria and viruses through their saliva. But here’s what’s changing: Tick species are being found in a wider geographic range. The number of case reports of tick-borne illnesses is increasing. Scientists continue to identify new pathogens (bacteria and viruses that c...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Infectious diseases Prevention Safety Travel health Source Type: blogs
Ticks and the diseases they carry have long been recognized as health concerns, especially in the warmer months when ticks (and humans) are more active. Ticks wait on grass tips or shrubs to latch onto new hosts when they brush by. Most of the hosts are animals, but a few tick species do bite and feed on humans. While doing so, they can transmit bacteria and viruses through their saliva. But here’s what’s changing: Tick species are being found in a wider geographic range. The number of case reports of tick-borne illnesses is increasing. Scientists continue to identify new pathogens (bacteria and viruses that c...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Infectious diseases Prevention Safety Travel health Source Type: blogs
Discussion Inflammation of the middle layer of the eye, or uvea, is termed uveitis. Uveitis can be divided into anterior, intermediate or posterior uveitis by involving the anterior (iris and ciliary body), intermediate (vitreous) or posterior (choroid and usually retina) compartments. Panuveitis involves all 3 compartments. Duration can also be used to classify uveitis. Acute is 6 weeks and> 3 months is chronic persistent uveitis. Episodic periods of inactivity and reactivity that last more than 3 months are called recurrent uveitis. A third way to characterize uveitis is if it is granulomatous or not. Uveitis increase...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
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