Chemical constituents from the South China sea soft coral Sinularia humilis.

Chemical constituents from the South China sea soft coral Sinularia humilis.
Nat Prod Res. 2020 Dec 24;:1-7
Authors: Li J, Huan XJ, Wu MJ, Chen ZH, Chen B, Miao ZH, Guo YW, Li XW
Abstract
A new diterpenoid with an unusual capnosane skeleton, sinuhumilol A (1), alone with twelve known diverse compounds (2-13), were isolated from the South China Sea soft coral Sinularia humilis. Their structures and stereochemistry were elucidated by extensive spectroscopic analysis, quantum chemical calculations, and/or by the comparison of the spectroscopic data with those reported in the literature. In bioassay, compound 11 exhibited interesting specific cytotoxicity against the human colon adenocarcinoma cell line HT-29 with IC50 value of 12.5 µM.
PMID: 33356576 [PubMed - as supplied by publisher]

Source: Natural Product Research - December 24, 2020 Category: Biochemistry Authors: Li J, Huan XJ, Wu MJ, Chen ZH, Chen B, Miao ZH, Guo YW, Li XW Tags: Nat Prod Res Source Type: research