The Potential Role of the Na/K-ATPase and its Signaling in Development of Anemia in Chronic Kidney Disease.

The Potential Role of the Na/K-ATPase and its Signaling in Development of Anemia in Chronic Kidney Disease. Am J Physiol Renal Physiol. 2020 Dec 28;: Authors: Maxwell KD, Chuang J, Chaudhry MA, Nie Y, Bai F, Sodhi K, Liu J, Shapiro JI Abstract Chronic kidney disease (CKD) is one of the most prominent diseases affecting our population today. According to the Factsheet published by Centers for Disease Control and Prevention (CDC), it effects approximately 15% of the total population in the United States in some way, shape, or form. Within the myriad of symptomatology associated with CKD, one of the most prevalent factors in terms of affecting quality of life is anemia. Anemia of CKD cannot be completely attributed to one mechanism or cause, but rather has a multifactorial origin in the pathophysiology of CKD. While briefly summarizing well-documented risk factors, this review, as a hypothesis, aims to explore the possible role of the Na/K-ATPase and its signaling function (especially recent identified ROS amplification function) in the interwoven mechanisms of development of the anemia of CKD. PMID: 33356956 [PubMed - as supplied by publisher]
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research