Quantification of 4-methylimidazol in plasma and cerebrospinal fluid (CSF) of mice using liquid ...

This study was the first report for determination of 4-MI in plasma and CSF samples in mice. Our results suggest that LC-MS/MS-based on ion-pair extraction is a robust method with high detection ability for measurement of 4-MI in plasma and CSF samples. Therefore the developed method can be useful for evaluation and monitoring of imidazole derivatives in biological samples.
Source: Iranian Journal of Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research