Isokinetic strength and degeneration of lower extremity muscles in patients with Myotonic Dystrophy; an MRI study

Myotonic dystrophy type 1 (DM1) is the most common adult-onset inherited muscular dystrophy characterized by progressive weakness of facial and distal skeletal muscles and myotonia [1]. Histological examinations and MRI scans have demonstrated muscle degeneration in DM1 including muscular fat infiltration and muscular atrophy. These abnormalities are primarily found in the distal muscles, most notably Mm. gastrocnemius caput mediale, soleus and tibialis anterior in the lower extremities [2-5] and M.
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research