Antiangiogenic activity of zinc and zinc-sorafenib combination using the chick chorioallantoic membrane assay: A descriptive study
Conclusion: Zinc caused significant antiangiogenic activity in the CAM assay. The lack of addition/synergism in the zinc-sorafenib combination could have been due to the variability in the dose/ratio selection. Addition of zinc to sorafenib therapy could improve treatment tolerability, reduce cost of therapy, and reduce the emergence of drug resistance. Future mechanistic studies could identify the exact pharmacodynamics of zinc as an angiogenesis inhibitor.
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Manu Kumar Girish Gulab Meshram Tripti Rastogi Sonal Sharma Rachna Gupta Seema Jain Anisha Prasad Vikas Galav SK Bhattacharya Source Type: research