Disrupted branched-chain amino acid catabolism impair cardiac insulin signaling and is associated with adverse cardiometabolic outcomes

Branched-chain amino acids (BCAAs), leucine (Leu), isoleucine (Ile) and valine (Val), account for ~20% of dietary protein intake [1]. BCAAs are reversibly transaminated to their corresponding branched-chain keto acids (BCKAs) by branched-chain aminotransferase (BCAT). BCKAs are oxidatively decarboxylated by branched-chain ketoacid dehydrogenase (BCKDH). BCKDH activity is inhibited by branched-chain ketoacid dehydrogenase kinase (BCKDK) mediated inhibitory phosphorylation or activated by protein phosphatase 2C (PP2Cm) induced dephosphorylation [1].
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Tags: Letter to the editor Source Type: research