Prophylactic antibiotics after endoscopic sinus surgery for chronic rhinosinusitis: a randomized, double ‐blind, placebo‐controlled noninferiority clinical trial

ConclusionAlthough statistically underpowered, the results suggest placebo was noninferior to prophylactic antibiotics after ESS for CRS regarding postoperative sinonasal ‐specific QOL. There were no significant differences in postoperative endoscopic scores or rates of infection, but the rate of diarrhea was significantly higher in the antibiotic group. These findings add to the growing evidence that routine use of prophylactic postoperative antibiotics does not i mprove outcomes post‐ESS and significantly increases the rate of diarrhea.
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research