Evaluation of segmental mandibular resection without a microvascular reconstruction in patients affected by medication-related osteonecrosis of the jaw: a systematic review

Medication-related osteonecrosis of the jaw (MRONJ) is a severe condition, which affects the jaw in patients exposed to specific drugs. More often, it has been described in association with patients receiving primarily bisphosphonate (BP) therapy. However, nowadays it has been observed with the usage of other medications, such as RANK ligand inhibitor and monoclonal antibody agent (Denosumab) and antiangiogenic drugs. Managing this condition has unfortunately proven difficult and still remains a major challenge for clinicians and surgeons.

Source: The British Journal of Oral and Maxillofacial Surgery - December 24, 2020 Category: ENT & OMF Authors: Roberto Sacco, Gezala Umar, Raphael Capelli Guerra, Oladapo Akintola Tags: Review Source Type: research