Therapeutic Approach Against 2019-nCoV by Inhibition of the ACE-2 receptor
Drug Res (Stuttg) DOI: 10.1055/a-1337-4462The continued spread of the 2019 novel coronavirus (2019-nCoV) has prompted
global concern. The formal name given to 2019-nCoV by the World Health
Organization is COVID-19, while the International Committee on Taxonomy has
named it severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Due
to this viral attack, nations around the world have issued lockdown
restrictions. Presently, there is no effective way to control the spread of
2019-nCoV, except through social distancing and hygienic activities.
World-class scientists and researchers are trying to develop vaccines and
medicines that will cure this deadly viral disease and control its spread.
Our aim in presenting this article is to provide an easy therapeutic
approach that effectively combats deadly viral diseases, such as COVID-19,
with minimal intervention and effort. Different Ayurvedic therapeutic agents
(Curcuma longa L, green tea, and Piper nigrum) inhibit the
entry of viruses in the host cell and the transmission of pathogens, while
improving immunity. Curcumin and piperine (1-piperoylpiperidine) interact
with each other and form a π–π intermolecular
complex that enhances the bioavailability of curcumin by inhibition of
glucuronidation of curcumin in the liver. Two molecules, curcumin and
catechin, bind directly to the receptor-binding domain of the S-protein and
the angiotensin-converting enzyme 2 receptor of the host cell, by which
these molecules inhibit the en...
Source: Drug Research - Category: Drugs & Pharmacology Authors: Kumar, Gajendra Kumar, Dharmendra Singh, Netra Pal Tags: Original Article Source Type: research
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