A Significant Association of Upper Limb Muscle Strength with Thyroid Function in Overweight and Obese Population: A Study of the Sixth Korea National Health and Nutrition Examination Survey (KNHANES 2014-2015).

A Significant Association of Upper Limb Muscle Strength with Thyroid Function in Overweight and Obese Population: A Study of the Sixth Korea National Health and Nutrition Examination Survey (KNHANES 2014-2015). Int J Endocrinol. 2020;2020:7195846 Authors: Lee J, Jo K, Ha J, Lim DJ, Lee JM, Chang SA, Kang MI, Kim MH Abstract Background. As skeletal muscle is one of main targets of thyroid hormone signalling, an association of thyroid function and muscle strength could be expected. The aim of study is to evaluate the association of free thyroxine (FT4) and thyrotropin (TSH) with upper limb muscle strength, measured by hand grip strength, in subjects with normal FT4 from national representative data. The study utilized the sixth edition of the Korea National Health and Nutrition Examination Survey. After exclusion of subjects with FT4 level out of normal range, a history of thyroid disease or cerebral disease, restricted activity, and incomplete data, a total of 3503 were recruited (age range 19-80 years, 51% male). FT4 positively correlated with upper limb muscle strength (β coefficient = -12.84, p < 0.001), while TSH did negatively (β coefficient = -0.37, p=0.002). After adjusting for confounding factors, statistical significance disappeared. However, among subjects with BMI above 23 kg/m2, a negative correlation of TSH with upper limb muscle strength was found in a younger age group (19-39 years old) (β coefficient ...
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research