Vascular endothelial growth factor mediates the sprouted axonogenesis of breast cancer in rat

Nerve infiltration into the tumor is a common feature of the tumor microenvironment. The mechanisms of axonogenesis in breast cancer remain unclear. We hypothesized that vescular endothelial growth factor (VEGF) as well as nerve growth factor (NGF) is involved in the axonogenesis of breast cancer. Here, we used a N-Methyl-N-Nitrosourea (MNU)-induced rat model of breast cancer to explore the presence of axonogenesis in breast tumor and the involvement of VEGF as well as NGF in the axonogenesis of breast tumor.

Source: American Journal of Pathology - December 23, 2020 Category: Pathology Authors: Hongxiu Han, Chunxue Yang, Yuan Zhang, Changhao Han, Guohua Zhang Source Type: research