Deletion of hepatic NCOR1 confers atheroprotection

Background and Aims: The nuclear receptor corepressor 1 (NCOR1) plays an important role in the regulation of gene expression under physiological and pathological conditions by connecting chromatin-modifying enzymes, coregulators and transcription factors. Recently we demonstrated that the deletion of macrophage NCOR1 aggravates the disease development by promoting CD36-triggered foam cell formation via PPAR γ derepression. Since NCOR1 acts as a central regulator of hepatic lipid homeostasis, we speculated that its deletion in the liver will also affect atherosclerosis development.
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research