The coatomer (COP I) complex limits the cell-surface abundance of the ldl receptor and cellular LDL uptake

Background and Aims: LDLR is the main regulator of LDL-c levels in plasma. For up to 40% of patients with familial hypercholesterolemia, the genetic origin is unknown. We here aimed at the discovery and validation of novel genes limiting the uptake of LDL into hepatocytes.

Source: Atherosclerosis - December 1, 2020 Category: Cardiology Authors: G. Panteloglou, P. Zanoni, L. Rohrer, J.A. Kuivenhoven, A. Rimbert, A. Tybjaerg-Hansen, N. Dalila, W. M ärz, A. Von Eckardstein Source Type: research