KIF4A enhanced cell proliferation and migration via Hippo signaling and predicted a poor prognosis in esophageal squamous cell carcinoma

ConclusionsIn summary, KIF4A promotes ESCC cell proliferation and migration by regulating the biological function of ESCC cells through the Hippo signaling pathway.Key pointsSignificant findings of the studyWe found that high KIF4A expression was associated with poor overall survival in esophageal squamous cell carcinoma. KIF4A expression also promoted the proliferation and migration of ESCC cells in vitro.What this study addsOur experimental results explain the role of KIF4A in ESCC, and provide a new biomolecular target for the treatment of ESCC.

Source: Thoracic Cancer - December 21, 2020 Category: Cancer & Oncology Authors: Xiaozheng Sun, Pengxiang Chen, Xue Chen, Wenjing Yang, Xuan Chen, Wei Zhou, Di Huang, Yufeng Cheng Tags: ORIGINAL ARTICLE Source Type: research