Impact of human papillomaviruses (HPV) on recurrence rate and malignant progression of sinonasal papillomas

The impact of HPV infection on recurrences and malignant transformation of sinonasal papillomas is elucidated. HPV infection rate is significantly higher in recurrent papillomas than in non ‐recurrent and the highest in papillomas with malignant progression. Most frequent HPV subtypes are HPV 6 in benign recurrent tumors, and HPV 16, 45, and 66 in malignant tumors, along with HPV 90 which is currently described for the first time in sinonasal papillomas. The data suggest that HPV inf ection is a risk factor for tumor recurrences. Malignant progression seems to be supported by high‐risk HPV genotypes (i.e., 16, 45, 66, and probably 90). AbstractSinonasal papillomas are characterized by their potential for frequent recurrences and malignant progression. Currently, the role of human papillomavirus (HPV) infection in sinonasal papillomas is unclear. A study was conducted to elucidate the impact of HPV infection on recurrence and malignant progression of sinonasal papillomas. One hundred and seven patients with 151 tumors could be examined. One hundred and one patients suffered from benign papilloma, mostly inverted papillomas (IP); six patients suffered from carcinomas in situ and squamous cell carcinomas (SCC) ex ‐IP. Recurrent IP were more often HPV‐positive than non‐recurrent tumors (38.8% vs. 60%–65%). Low‐risk (LR) HPV infection (especially HPV 6) increased the risk of tumor recurrences (p = 0.0385 andp = 0.0556, respectively). IP and oncocytic papillomas (...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research