GSE152168 Borrelia burgdorferi infection induces long-term memory-like responses in macrophages with tissue-wide consequences in the heart

Contributors : Diego Barriales ; Itziar Mart ín ; Ana Carreras-González ; Marta Montesinos-Robledo ; Mikel Azkargorta ; Ibon Iloro ; Iraide Escobés ; Teresa Martín-Mateos ; Estibaliz Atondo ; Ainhoa Palacios ; Monika Gonzalez ; Diana Cabrera ; Ainize Peña-Cearra ; Sebastiaan M van Liempd ; Juan M Falcón-Pérez ; Miguel A Pascu al-Itoiz ; Leticia Abecia ; Aize Pellon ; Maria L Martínez-Chantar ; Ana M Aransay ; Alberto Pascual ; Felix Elortza ; Edurne Berra ; José L Lavín ; Héctor Rodríguez ; Juan AnguitaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLyme carditis is an extracutaneous manifestation of Lyme disease characterized by episodes of atrioventricular block of varying degrees and other less reported cardiomyopathies. The molecular changes associated with the response to Borrelia burgdorferi over the course of infection are poorly understood. Here, we identify broad transcriptomic and proteomic changes in the heart during infection that reveal a profound downregulation of mitochondrial components. We also characterize the long-term functional modulation of macrophages exposed to live bacteria, characterized by an augmented glycolytic output, increased spirochetal binding and internalization, and reduced IRF-4-dependent inflammatory responses. In vitro, glycolysis inhibition reduces the production of TNF by memory macrophages whereas in vivo, it produces the reversion of the Irf4-induced memory phenot...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research