Separate signaling events control TCR downregulation and T cell activation in primary human T cells
ConclusionsThese data suggest that there is substantial redundancy in the contribution of individual tyrosine kinases to TCR downregulation in primary human T cells. Our results highlight that TCR downregulation and T cell activation are controlled by different signaling events and illustrate the need for further research to untangle these processes.
Source: Immunity, Inflammation and Disease - Category: Allergy & Immunology Authors: Lieve E. H. Donk,
Louis S. Ates,
Jet Spek,
Laura M. Tukker,
Teunis B. H. Geijtenbeek,
Jeroen W. J. Heijst Tags: ORIGINAL RESEARCH Source Type: research