Circulating cell-free mitochondrial DNA fragment: A possible marker for early detection of Schistosoma japonicum.

In this study, we explored the usefulness of the mitochondrial cfDNA markers for the diagnosis of schistosomiasis from the experimentally infected hosts (rabbits and mice). In this study we found mitochondrial DNA fragment cytochrome B gene as persistent and useful cfDNA marker for the early detection of schistosomiasis. We evaluated the sensitivity of cfDNA marker with varying numbers of cercaria. Overall, our results suggest that cfDNA markers can be useful for developing a diagnostic tool for the detection of S. japonicum infection. PMID: 33348056 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33348056?dopt=Abstract

Source: Infection, Genetics and Evolution - December 18, 2020 Category: Genetics & Stem Cells Authors: Ullah H, Arbab S, Khan MIU, Li K, Muhammad N, Suleman, Qadeer A, Wangdan, Sato MO Tags: Infect Genet Evol Source Type: research