TGF β Signaling in Photoaging and UV-Induced Skin Cancer

UVR is a major etiology for premature skin aging that leads to photoaging and UV-induced skin cancers. In the skin, TGF β signaling is a growth inhibitor for keratinocytes and a profibrotic factor in the dermis. It exerts context-dependent effects on tumor progression. Chronic UV exposure likely causes TGFβ1/SMAD3 signaling activation and contributes to metalloproteinase-induced collagen degradation and photoinflam mation in photoaging. UV irradiation also causes gene mutations in key elements of the TGFβ pathway, including TGFβRI, TGFβRII, SMAD2, and SMAD4.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Review Source Type: research