Feeding regulation by oleoylethanolamide synthesized from dietary oleic acid

Fatty acid ethanolamides (FAEs), lipid mediators in both plant and animal tissues, are involved in a variety of biological functions. Among the members of the FAE family, arachidonoylethanolamide (anandamide) is known to serve as an endogenous ligand for cannabinoid receptors, and plays important roles in neuroprotection, hypotension, pain relief, and feeding stimulation [1-3]. Other members of the FAE family, such as oleoylethanolamide (OEA; Fig. 1) and palmitoylethanolamide (PEA), are not ligands of cannabinoid receptors but are instead involved in specific biological effects through receptors such as GPR119, peroxisome proliferator-activated receptor type- α (PPAR-α), and transient receptor potential vanilloid 1 (TRPV1) [4-6].
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - Category: Biomedical Science Authors: Source Type: research