Change in newly diagnosed Graves ’ disease phenotype between the twentieth and the twenty-first centuries: meta-analysis and meta-regression

ConclusionsOur meta-analysis and meta-regression confirmed that GD phenotype at diagnosis is nowadays milder than in the past; we hypothesize that conceivable factors involved in this change are iodoprophylaxis, worldwide decrease in smoking habits, larger use of contraceptive pill and micronutrient supplementation, as well as earlier diagnosis and management.
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research