Tick peptides evoke itch by activating MrgprC11/X1 to sensitize TRPV1 in pruriceptors

Anti-histamine treatment does not improve the itching symptoms of patients bitten by ticks. Tick salivary peptides induce itch via the MrgprC11/X1-TRPV1 signaling pathway, providing potential drug targets for treatment of the disease.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research