All ‐cause and cardiovascular disease mortality in underweight patients with diabetic nephropathy: BioBank Japan Cohort

AbstractWe aimed to determine mortality risk in underweight patients with diabetic nephropathy for microalbuminuria or macroalbuminuria. We analyzed mortality and death ‐cause data from BioBank Japan, with baseline years 2003–2007. We analyzed mortality rates from all causes and ischemic heart disease, according to body mass index (<18.5, 18.5 –21.9, 22–24.9, and ≥25 kg/m2). Mean (standard deviation) of patients ’ age, body mass index, and glycated hemoglobin at enrollment was 61.6 (11.7) years, 25.0 (4.4) kg/m2, and 7.7% (1.5)%, respectively. Hazard ratios of all ‐cause and ischemic heart disease mortality were highest (1.79 (p=0.0001) and 2.95 (p=0.027), respectively) in patients with body mass index<18.5 kg/m2, as compared with body mass index 22 –24.9 kg/m2. All ‐cause mortality risk for body mass index<18.5 kg/m2 was similar to that for current smokers (hazard ratio 1.70, p<0.0001). Underweight could be a predictor of mortality risk in patients with diabetic nephropathy for microalbuminuria or macroalbuminuria.

Source: Journal of Diabetes Investigation - December 19, 2020 Category: Endocrinology Authors: Hiroshi Yokomichi, Mie Mochizuki, Makoto Hirata, Akiko Nagai, Reiji Kojima, Sayaka Horiuchi, Tadao Ooka, Yuka Akiyama, Ryoji Shinohara, Kunio Miyake, Project BioBank Japan, Zentaro Yamagata Tags: SHORT REPORT Source Type: research