Rapid effective dose calculation for raster-scanning 4He ion therapy with the modified microdosimetric kinetic model (mMKM)

With favorable depth dose deposition for a high precision tumor targeting, particle therapy has become increasingly available. Over the last decade, the Heidelberg Ion-Beam Therapy Center (HIT) has treated>5000 patients using protons (p) and carbon ion (12C) beams [1] with additional helium (4He) and oxygen ion (16O) beams for physics and biological in vitro and in vivo research. Since initial experimentation and clinical application at the Lawrence Berkeley Laboratory during the last century, 4He ion beams have remained clinically dormant.

Source: Physica Medica: European Journal of Medical Physics - December 19, 2020 Category: General Medicine Authors: B. Kopp, S. Mein, T. Tessonnier, J. Besuglow, S. Harrabi, E. Heim, A. Abdollahi, T. Haberer, J. Debus, A. Mairani Tags: Original paper Source Type: research