PNA-encoded chemical libraries.

PNA-encoded chemical libraries.
Curr Opin Chem Biol. 2015 Jan 23;26C:8-15
Authors: Zambaldo C, Barluenga S, Winssinger N
Abstract
Peptide nucleic acid (PNA)-encoded chemical libraries along with DNA-encoded libraries have provided a powerful new paradigm for library synthesis and ligand discovery. PNA-encoding stands out for its compatibility with standard solid phase synthesis and the technology has been used to prepare libraries of peptides, heterocycles and glycoconjugates. Different screening formats have now been reported including selection-based and microarray-based methods that have yielded specific ligands against diverse target classes including membrane receptors, lectins and challenging targets such as Hsp70.
PMID: 25621730 [PubMed - as supplied by publisher]

Source: Current Opinion in Chemical Biology - January 23, 2015 Category: Biochemistry Authors: Zambaldo C, Barluenga S, Winssinger N Tags: Curr Opin Chem Biol Source Type: research