Multifunctionality of F-rich nucleoporins.

Multifunctionality of F-rich nucleoporins.
Biochem Soc Trans. 2020 Dec 18;:
Authors: Heinß N, Sushkin M, Yu M, Lemke EA
Abstract
Nucleoporins (Nups) represent a range of proteins most known for composing the macromolecular assembly of the nuclear pore complex (NPC). Among them, the family of intrinsically disordered proteins (IDPs) phenylalanine-glycine (FG) rich Nups, form the permeability barrier and coordinate the high-speed nucleocytoplasmic transport in a selective way. Those FG-Nups have been demonstrated to participate in various biological processes besides nucleocytoplasmic transport. The high number of accessible hydrophobic motifs of FG-Nups potentially gives rise to this multifunctionality, enabling them to form unique microenvironments. In this review, we discuss the multifunctionality of disordered and F-rich Nups and the diversity of their localizations, emphasizing the important roles of those Nups in various regulatory and metabolic processes.
PMID: 33336681 [PubMed - as supplied by publisher]

Source: Biochemical Society Transactions - December 18, 2020 Category: Biochemistry Authors: Heinß N, Sushkin M, Yu M, Lemke EA Tags: Biochem Soc Trans Source Type: research