A new cyclic peptide from the fibrous root of Pseudostellaria heterophylla.

A new cyclic peptide from the fibrous root of Pseudostellaria heterophylla.
Nat Prod Res. 2020 Dec 17;:1-7
Authors: Zhao XF, Zhang Q, Zhao HT, Zhang YD, Liu HR, Yuan LJ, Chen QF
Abstract
A new cyclic peptide, Pseudostellarin K (1), together with thirteen known compounds, including two cyclic peptides (2 and 3), one β-carboline alkaloid (4), two amides (5 and 6), three phenylpropanoids (7-9) and other compounds (10-14), were isolated from the fibrous root of Pseudostellaria heterophylla. Their structures were elucidated by extensive spectroscopic analysis. Compounds 1, 4-6, 10 were isolated from the genus pseudostellaria for the first time. All compounds were evaluated for cytotoxic activities against MCF-7, A549, HCT-116 and SGC-7901 cell lines by MTT assay. Unfortunately, all these compounds displayed weak cytotoxic activities.
PMID: 33331165 [PubMed - as supplied by publisher]

Source: Natural Product Research - December 17, 2020 Category: Biochemistry Authors: Zhao XF, Zhang Q, Zhao HT, Zhang YD, Liu HR, Yuan LJ, Chen QF Tags: Nat Prod Res Source Type: research