This Month in AJP

The lack of relevant animal models has limited our understanding of COVID-19 pathobiology and testing possible interventions. Using aged African green monkeys (AGMs) infected with SARS-CoV-2, Blair et al (Am J Pathol, AJPA-D-20-00470) modeled acute respiratory distress syndrome (ARDS), which is a common symptom in severely ill COVID-19 patients, and often a cause of death. Eight aged AGMs were exposed to SARS-CoV2 and they exhibited mild to severe COVID-19 with increased levels of plasma interleukin-6, a predictive biomarker and potential therapeutic target.
Source: American Journal of Pathology - Category: Pathology Tags: This Month in AJP Source Type: research