Soluble interleukin-2 receptor in exhaled breath condensate in pulmonary sarcoidosis: a cross-sectional pilot study
Introduction . Sarcoidosis is a chronic granulomatous disease of unknown aetiology with a variable
clinical course and prognosis. There is an urgent need to identify new and novel biomarkers to help
differentiate between clinical phenotypes and guide clinical decisions with respect to commencing
and monitoring treatment. Across the spectrum of respiratory disease there has been a growing
interest in the role of breath-based biomarkers given their non-invasive nature and ability to
repeat sampling with ease for serial monitoring. Soluble interleukin-2 receptor (sIL2R) in
bronchoalveolar lavage and serum correlates with disease activity in sarcoidosis; however, no
previous study has evaluated sIL2R in exhaled breath. Objectives . The main aim of this
cross-sectional case-controlled pilot study was to determine the concentration of sIL2R in exhaled
breath condensate (EBC) from patients with recently diagnosed sarcoidosis compared to healthy
volunteers and to establish,...
Source: Journal of Breath Research - Category: Respiratory Medicine Authors: Dayle L Terrington, Jee Whang Kim, Garth Ravenhill, Jonathan Tang, Isabelle Piec, Stephen J Fowler, William Fraser and Andrew M Wilson Source Type: research