Physical training and exercise in myasthenia gravis

Myasthenia gravis (MG) is an autoimmune disease with antibodies that bind to the postsynaptic membrane on skeletal muscle cells. These antibodies impair the function of acetylcholine receptors (AChR), increase their degradation and induce morphological changes in the membrane [1]. The antibodies are directed against the extracellular part of the AChR itself, or against membrane proteins that functionally interact with AChR; muscle-specific tyrosine kinase (MuSK) or lipoprotein-related peptide 4 (LRP4).
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research