Quantitative Emphysema on Low-Dose Computed Tomography of the Chest and Risk of Lung Cancer and Airflow Obstruction: An analysis of the National Lung Screening Trial.

Quantitative Emphysema on Low-Dose Computed Tomography of the Chest and Risk of Lung Cancer and Airflow Obstruction: An analysis of the National Lung Screening Trial. Chest. 2020 Dec 13;: Authors: Labaki WW, Xia M, Murray S, Hatt CR, Al-Abcha A, Ferrera MC, Meldrum CA, Keith LA, Galbán CJ, Arenberg DA, Curtis JL, Martinez FJ, Kazerooni EA, Han MK Abstract BACKGROUND: Lung cancer risk prediction models do not routinely incorporate imaging metrics available on low-dose computed tomography (LDCT) of the chest ordered for lung cancer screening. RESEARCH QUESTION: What is the association between quantitative emphysema measured on LDCT and lung cancer incidence and mortality, all-cause mortality, and airflow obstruction in individuals who currently or formerly smoked undergoing lung cancer screening? STUDY DESIGN AND METHODS: In 7,262 participants in the CT arm of the National Lung Screening Trial, % low attenuation area (%LAA) was defined as the percent of lung volume with voxels < -950 Hounsfield Units on the baseline exam. We built multivariable Cox proportional hazards models, adjusting for competing risks where appropriate, to test for association between %LAA and lung cancer incidence, lung cancer mortality and all-cause mortality with censoring at 6 years. We also built multivariable logistic regression models to test the cross-sectional association between %LAA and airflow obstruction on spirometry which was ava...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research