Effect of Tumor Perfusion and Receptor Density on Tumor Control Probability in 177Lu-DOTATATE Therapy: An In Silico Analysis for Standard and Optimized Treatment

Conclusion: PBPK modeling and simulations represent an elegant approach to individually determine the minimal tumor perfusion and minimal receptor density required to achieve an adequate TCP. This computational method can be used in the radiopharmaceutical development process for ligand and target selection for specific types of tumors. In addition, this method could be used to optimize clinical trials.

Source: Journal of Nuclear Medicine - December 17, 2020 Category: Nuclear Medicine Authors: Jimenez-Franco, L. D., Glatting, G., Prasad, V., Weber, W. A., Beer, A. J., Kletting, P. Tags: Basic Source Type: research