Back Cover: The Beneficial Effects of Apical Sodium ‐Dependent Bile Acid Transporter Inactivation Depend on Dietary Fat Composition

Mol. Nutr. Food Res. 2020,64,2000750DOI:10.1002/mnfr.202000750Inactivation of the apical sodium bile acid transporter (ASBT) interrupts the enterohepatic circulation of bile acids and subsequently impairs lipid absorption.Asbt−/− mice are protected from obesity, insulin resistance and fatty liver disease when fed a high ‐fat diet rich in saturated but not polyunsaturated fatty acids, highlighting the importance of dietary composition in assessment of treatments targeting bile acid homeostasis. This is reported by Ivo P. van de Peppel, Anuradha Rao, Marleen B. Dommerholt, Laura Bongiovanni, Rachel Thomas, Alain de Bruin, Saul J. Karpen, Paul A. Dawson, Henkjan J. Verkade, Johan W. Jonker in article number2000750.
Source: Molecular Nutrition and Food Research - Category: Food Science Authors: Tags: Back Cover Source Type: research