Palmitic Acid Methyl Ester Inhibits Cardiac Arrest-Induced Neuroinflammation and Mitochondrial Dysfunction

We previously discovered that palmitic acid methyl ester (PAME) is a potent vasodilator released from the sympathetic ganglion with vasoactive properties. Post-treatment with PAME can enhance cortical cerebral blood flow and functional learning and memory, while inhibiting neuronal cell death in the CA1 region of the hippocampus under pathological conditions (i.e. cerebral ischemia). Since mechanisms underlying PAME-mediated neuroprotection remain unclear, we investigated the possible neuroprotective mechanisms of PAME after 6 min of asphyxia cardiac arrest (ACA, an animal model of global cerebral ischemia).

Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - December 16, 2020 Category: Biomedical Science Authors: Celeste Yin-Chieh Wu, Alexandre Couto e Silva, Cristiane T. Citadin, Garrett A. Clemons, Christina H Acosta, Brianne A Knox, Mychal S. Grames, Krista M Rodgers, Reggie Hui-Chao Lee, Hung Wen Lin Source Type: research