Defective STING expression potentiates IL-13 signaling in epithelial cells in eosinophilic chronic rhinosinusitis with nasal polyps

Capsule summary: Downregulated STING expression caused by type 2 cytokines impairs type I interferon production but exaggerates eosinophilic inflammation in CRSwNP. STING functions as a suppressor of IL-13 signaling in airway epithelial cells.

Source: Journal of Allergy and Clinical Immunology - December 16, 2020 Category: Allergy & Immunology Authors: Hai Wang, Dan-Qing Hu, Qiao Xiao, Yi-Bo Liu, Jia Song, Yuxia Liang, Jian-Wen Ruan, Zhe-Zheng Wang, Jing-Xian Li, Li Pan, Meng-Chen Wang, Ming Zeng, Li-Li Shi, Kai Xu, Qin Ning, Guohua Zhen, Di Yu, De-Yun Wang, Sally E. Wenzel, Zheng Liu Source Type: research