Identification of distinct immunophenotypes in critically-ill COVID-19 patients.

Identification of distinct immunophenotypes in critically-ill COVID-19 patients. Chest. 2020 Dec 11;: Authors: Dupont T, Caillat-Zucman S, Fremeaux-Bacchi V, Morin F, Lengliné E, Darmon M, Peffault de Latour R, Zafrani L, Azoulay E, Dumas G Abstract BSACKGROUND: Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) infection causes direct lung damage, overwhelming endothelial activation and inflammatory reaction leading to acute respiratory failure and multi-organ dysfunction. Ongoing clinical trials are evaluating targeted therapies to hinder this exaggerated inflammatory response. Critically-ill COVID-19 patients have shown heterogeneous severity trajectories, suggesting that response to therapies is likely to vary across patients. RESEARCH QUESTION: Are critically-ill COVID-19 patients biologically and immunologically dissociable based on profiling of currently evaluated therapeutic targets? STUDY DESIGN AND METHODS: We did a single-center, prospective study in an ICU department in France. Ninety-six critically-ill adult patients admitted with a documented SARS-CoV-2 infection were enrolled. We conducted principal components analysis and hierarchical clustering on a vast array of immunologic variables measured on the day of ICU admission. RESULTS: We found that patients were distributed in three clusters bearing distinct immunologic features and associated to different ICU outcomes. Cluster 1 had a ...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research